sys.path has an unwritable __pycache__ directory.

This typically comes up when someone runs the test suite from an
administrative install of Python on Windows where the user does not
have write permissions to the stdlib's directory.

Thanks to Zachary Ware and Matthias Klose for reporting bugs related
to this issue.
(grafted from 34bbd537b3e688dfbb6498e9083445a6a72fc4b1)